TB-500 5mg Research Peptide Vial

TB-500 5mg — Thymosin Beta-4 Fragment for Tissue Repair & Regeneration Research

Full Description

TB-500 is a synthetic heptapeptide (Ac-LKKTETQ) that corresponds to the active actin-binding domain of thymosin beta-4. It is widely investigated in preclinical research for its roles in promoting cell migration, angiogenesis, tissue repair, and wound healing across multiple injury and disease models.

What It Is

• Class: Synthetic thymosin beta-4 fragment (heptapeptide)

• Concept: Mimics key biological activities of thymosin beta-4 by regulating actin dynamics to facilitate cell migration, vascular growth, and tissue regeneration in research settings.

• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Actin Regulation & Cell Migration

• Binds to G-actin, modulating actin polymerization and depolymerization to promote cytoskeletal reorganization.

• Enhances migration of endothelial cells, fibroblasts, keratinocytes, and stem/progenitor cells to sites of injury.

Angiogenesis & Tissue Repair

• Stimulates formation of new blood vessels (angiogenesis) to improve nutrient and oxygen delivery in damaged tissues.

• Supports extracellular matrix remodeling, collagen organization, and accelerated wound closure in various models.

Anti-Inflammatory & Cytoprotective Effects

• Reduces excessive inflammation and apoptosis while protecting cells from cytotoxic stress.

• Investigated for modulation of inflammatory pathways and support of functional tissue recovery.

Selected Research Highlights

• Wound Healing: Studied for accelerated closure of dermal, corneal, and excisional wounds with improved re-epithelialization and reduced scarring.

• Musculoskeletal Injury: Explored for enhanced repair of tendons, ligaments, muscles, and bones in injury models, with improved tensile strength and recovery.

• Angiogenesis: Demonstrated promotion of new vessel formation and increased blood flow in ischemic and injured tissues.

• Cardiac & Organ Protection: Investigated for cardioprotective effects, reduction of fibrosis, and support of tissue regeneration in cardiac injury models.

• Anti-Inflammatory Action: Shown to modulate inflammatory responses and decrease myofibroblast formation in healing tissues.

Chemical & Handling Information

• Type: Synthetic heptapeptide fragment of thymosin beta-4

• Sequence: Ac-LKKTETQ

• Appearance: White to off-white lyophilized powder

Specifications

• Peptide: TB-500

• Amount: 5 mg per vial

• Form: Lyophilized powder

• Purity: ≥99% (HPLC) – Certificate of Analysis available per lot

• Packaging: Sealed vials suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place protected from light.

• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability according to laboratory SOPs.

• After reconstitution: Store at 2–8 °C for short-term use.

• Long-term storage: Aliquot and freeze at –20 °C or below. Avoid repeated freeze-thaw cycles.