Semax 10mg Research Peptide Vial

Full Description

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analog of the adrenocorticotropic hormone (ACTH) fragment 4-10. It is extensively investigated in preclinical research for its potent neuroprotective, neurotrophic, and cognitive-enhancing properties. Semax lacks significant hormonal activity compared to full ACTH while demonstrating strong effects on brain-derived neurotrophic factor (BDNF), neuronal survival, synaptic plasticity, and recovery in models of neurological stress and cognitive impairment.

What It Is

• Class: Synthetic ACTH (4-10) analog (nootropic/neuroprotective heptapeptide)

• Concept: Mimics select neurotrophic and neuromodulatory actions of endogenous ACTH fragments to support neuronal repair, plasticity, and cognitive performance in research settings.

• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Neurotrophic & Neuroprotective Effects

• Upregulates expression of BDNF, NGF, and other neurotrophins in hippocampal and cortical neurons.

• Protects neurons from oxidative stress, hypoxia, glutamate excitotoxicity, and other insults.

Cognitive & Synaptic Plasticity

• Enhances long-term potentiation (LTP), synaptic transmission, and dendritic spine density in key brain regions.

• Modulates multiple neurotransmitter systems including dopamine, serotonin, and acetylcholine.

Anti-Inflammatory & Gene Regulation

• Reduces neuroinflammation and modulates expression of genes involved in neuronal survival, differentiation, and repair.

• Supports cerebral blood flow and angiogenesis in ischemic and injury models.

Selected Research Highlights

• Neuroprotection: Demonstrated robust protective effects in models of ischemic stroke, traumatic brain injury, and neurotoxic exposure.

• Cognitive Enhancement: Investigated for improvements in learning, memory retention, attention, and executive function in various behavioral paradigms.

• BDNF Upregulation: Strongly associated with increased BDNF levels and enhanced neuroplasticity in hippocampal and cortical research models.

• Optic Nerve & Retinal Protection: Explored for neuroprotective benefits in models of optic nerve damage and glaucoma.

• Stress & Recovery: Studied for normalization of stress-induced behavioral and biochemical changes, supporting recovery after perinatal hypoxia and other neurological insults.

• Neurodevelopmental Models: Examined for support of neuronal maturation and recovery in developmental research settings.

Chemical & Handling Information

• Type: Synthetic heptapeptide

• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP)

• Molecular Formula: C₃₇H₅₁N₁₁O₁₀S

• Molecular Weight: ≈813.9 g/mol

• Appearance: White to off-white lyophilized powder

Specifications

• Peptide: Semax

• Amount: 10 mg per vial

• Form: Lyophilized powder

• Purity: ≥99% (HPLC) – Certificate of Analysis available per lot

• Packaging: Sealed vials suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place protected from light.

• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability according to laboratory SOPs.

• After reconstitution: Store at 2–8 °C for short-term use.

• Long-term storage: Aliquot and freeze at –20 °C or below. Avoid repeated freeze-thaw cycles.