Selank 10mg Peptide Research Vial

Selank 10 mg — Synthetic Heptapeptide for Anxiolytic & Nootropic Research

Full Description

Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is a synthetic heptapeptide analog of the endogenous immunomodulatory tetrapeptide tuftsin. It is extensively investigated in preclinical research for its anxiolytic, nootropic, and immunomodulatory properties. Unlike classical benzodiazepines, Selank is studied for producing calming and cognitive-enhancing effects without sedation, muscle relaxation, or dependence in research models.

What It Is

• Class: Synthetic tuftsin-derived heptapeptide (anxiolytic bioregulator)

• Concept: Combines neuromodulatory and immunoregulatory actions to support stress resilience, cognitive function, and balanced immune responses in preclinical models.

• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Neurotransmitter & Anxiolytic Pathways

• Acts as a positive allosteric modulator of GABA-A receptors, enhancing inhibitory signaling without benzodiazepine-like side effects.

• Inhibits enkephalin-degrading enzymes, prolonging the action of endogenous opioids involved in stress modulation.

Cognitive & Neuroprotective Effects

• Influences expression of genes related to neuroplasticity, BDNF, and neurotransmitter systems in hippocampal and cortical models.

• Modulates serotonin and dopamine metabolism in brain regions associated with anxiety and cognition.

Immunomodulatory Action

• Balances Th1/Th2 cytokine profiles and supports interferon production in immune research models.

• Exhibits antiviral and anti-inflammatory properties secondary to immune regulation.

Selected Research Highlights

• Anxiolytic Effects: Demonstrated reduction of anxiety-like behaviors in multiple rodent stress and conflict models, comparable to classical anxiolytics but without sedation.

• Nootropic & Cognitive Support: Investigated for improvements in learning, memory, and attention in various behavioral paradigms.

• Stress Protection: Studied for normalization of stress-induced changes in behavior and biochemical markers (cortisol, BDNF).

• Immunoregulation: Explored for modulation of cytokine balance and enhancement of antiviral responses in preclinical infection models.

• Neuroprotection: Shown to influence gene expression profiles in brain tissue related to neuroplasticity and neuroprotection.

• Safety Profile: Extensively examined for lack of sedative, myorelaxant, or addictive potential in animal models.

Chemical & Handling Information

• Type: Synthetic heptapeptide

• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (TKPRPGP)

• Molecular Formula: C₃₃H₅₇N₁₁O₉

• Molecular Weight: ≈751.9 g/mol

• Appearance: White to off-white lyophilized powder

Specifications

• Peptide: Selank

• Amount: 10 mg per vial

• Form: Lyophilized powder

• Purity: ≥99% (HPLC) – Certificate of Analysis available per lot

• Packaging: Sealed vials suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place protected from light.

• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability according to laboratory SOPs.

• After reconstitution: Store at 2–8 °C for short-term use.

• Long-term storage: Aliquot and freeze at –20 °C or below. Avoid repeated freeze-thaw cycles.