PT-141 10mg Research Peptide Vial

PT-141 10 mg — Melanocortin Receptor Agonist for Sexual & Neuroendocrine Function Research

Full Description

PT-141 (Bremelanotide) is a synthetic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). It is extensively investigated in preclinical research as a potent agonist of melanocortin receptors (primarily MC4R and MC3R), with studied effects on central nervous system pathways involved in sexual arousal, desire, and neuroendocrine regulation, independent of vascular mechanisms.

What It Is

• Class: Synthetic melanocortin receptor agonist (α-MSH analog)

• Concept: Selectively activates central melanocortin pathways to modulate sexual behavior and appetitive responses in research models, offering a non-vascular mechanism of action distinct from PDE5 inhibitors.

• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Melanocortin Receptor Activation

• High-affinity agonist at MC4R (and to a lesser extent MC3R) in the central nervous system, particularly in hypothalamic and limbic regions.

• Triggers downstream signaling via cAMP elevation and modulation of neuronal activity.

Central Neuroendocrine Effects

• Activates pathways in the hypothalamus and medial preoptic area involved in sexual motivation and arousal.

• Enhances dopaminergic neurotransmission in reward and sexual behavior circuits.

Additional Pathways

• Investigated for modulation of inflammatory responses and potential neuroprotective effects via melanocortin signaling.

Selected Research Highlights

• Sexual Function Models: Demonstrated dose-dependent increases in sexual arousal and mounting behavior in female and male rodent models.

• Non-Vascular Mechanism: Shown to exert effects centrally rather than through vasodilation, distinguishing it from traditional erectile dysfunction research compounds.

• Hypothalamic Activation: Induces Fos expression in key brain regions associated with sexual behavior and energy homeostasis.

• Melanocortin System Research: Extensively used as a tool compound to study MC4R-mediated pathways in appetite, sexual function, and stress responses.

• Comparative Studies: Compared with other melanocortin analogs for receptor selectivity and behavioral outcomes in preclinical settings.

Chemical & Handling Information

• Type: Synthetic cyclic heptapeptide

• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH

• Molecular Formula: C₅₀H₆₈N₁₄O₁₀

• Molecular Weight: ≈1025.2 g/mol

• Appearance: White to off-white lyophilized powder

Specifications

• Peptide: PT-141 (Bremelanotide)

• Amount: 10 mg per vial

• Form: Lyophilized powder

• Purity: ≥99% (HPLC) – Certificate of Analysis available per lot

• Packaging: Sealed vials suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place protected from light.

• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability according to laboratory SOPs.

• After reconstitution: Store at 2–8 °C for short-term use.

• Long-term storage: Aliquot and freeze at –20 °C or below. Avoid repeated freeze-thaw cycles.