NAD+ 100mg Research Vial

NAD+ 100 mg — Nicotinamide Adenine Dinucleotide for Cellular Energy & Longevity Research

Full Description

NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme found in all living cells. It is extensively investigated in preclinical and translational research for its central role in cellular energy metabolism, mitochondrial function, DNA repair, and sirtuin activation. NAD+ levels naturally decline with age and in various disease models, making it a key focus in studies of metabolic health, aging, and cellular resilience.

What It Is

• Class: Essential redox coenzyme and substrate for sirtuins, PARPs, and CD38

• Concept: Serves as a critical cofactor in hundreds of enzymatic reactions, supporting energy production, genomic stability, and cellular signaling pathways relevant to aging and metabolic stress.

• Format: Research-grade synthetic compound supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Mitochondrial Function & Energy Metabolism

• Acts as an electron carrier in redox reactions (NAD+/NADH) essential for glycolysis, TCA cycle, and oxidative phosphorylation.

• Supports mitochondrial biogenesis and efficiency via SIRT1 and SIRT3 activation.

DNA Repair & Genomic Stability

• Serves as a substrate for poly(ADP-ribose) polymerases (PARPs) involved in DNA damage repair.

• Enhances sirtuin-mediated deacetylation of histones and transcription factors, promoting cellular stress resistance.

Sirtuin Activation & Anti-Aging Pathways

• Activates sirtuins (particularly SIRT1), which regulate inflammation, autophagy, and metabolic homeostasis.

• Investigated for counteracting age-related NAD+ decline and associated metabolic dysfunction.

Selected Research Highlights

• Aging & Longevity: Studied for restoration of NAD+ levels in aged models, with associated improvements in mitochondrial function, physical performance, and healthspan markers.

• Metabolic Health: Explored for beneficial effects on insulin sensitivity, lipid metabolism, and body composition in obesity and type 2 diabetes models.

• Neuroprotection: Investigated in models of neurodegenerative conditions for support of neuronal energy metabolism, reduced oxidative stress, and cognitive parameters.

• Cardiovascular Research: Examined for cardioprotective effects, improved endothelial function, and mitigation of age-related vascular decline.

• Muscle & Exercise Recovery: Associated with enhanced muscle endurance, recovery, and mitochondrial adaptations in preclinical exercise models.

• Immune & Inflammatory Modulation: Studied for regulation of inflammatory responses and immune cell function via NAD+-dependent signaling.

Chemical & Handling Information

• Type: Nicotinamide adenine dinucleotide (oxidized form)

• Molecular Formula: C₂₁H₂₆N₇O₁₄P₂ (oxidized NAD+)

• Molecular Weight: ≈663.43 g/mol

• Appearance: White to off-white lyophilized powder

Specifications

• Compound: NAD+ (Nicotinamide Adenine Dinucleotide)

• Amount: 100 mg per vial

• Form: Lyophilized powder

• Purity: ≥99% (HPLC) – Certificate of Analysis available per lot

• Packaging: Sealed vials suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place protected from light.

• Refrigeration or freezing of the lyophilized compound is recommended for extended stability according to laboratory SOPs.

• After reconstitution: Store at 2–8 °C for short-term use.

• Long-term storage: Aliquot and freeze at –20 °C or below. Avoid repeated freeze-thaw cycles.