MOTS-c 20 mg Case of 10

Main Title

MOTS-c 20 mg — Mitochondrial-Derived Peptide for Metabolic Homeostasis Research

Full Description

MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene rather than the nuclear genome. Identified in 2015, it is investigated in preclinical research as a mitochondrial-derived peptide (MDP) that regulates metabolic homeostasis, AMPK signaling, insulin sensitivity, and adaptive gene expression under metabolic stress in models of obesity, aging, and energy imbalance.

What It Is

• Class: Mitochondrial-derived peptide (MDP / microprotein)

• Concept: Encoded in mtDNA and studied as a mitochondria-to-nucleus signaling peptide that activates AMPK, supports glucose and lipid utilization, and helps coordinate cellular energy and stress responses.

• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

AMPK & One-Carbon Metabolism

• Investigated for modulation of the folate–methionine cycle and de novo purine biosynthesis, leading to AICAR accumulation and AMPK activation.

• AMPK activation is studied for downstream effects on glucose uptake, fatty-acid oxidation, and energy-sensing pathways in skeletal muscle models.

Mitochondria-to-Nucleus Signaling

• Under metabolic or oxidative stress, MOTS-c is studied for translocation from mitochondria to the nucleus.

• In the nucleus, it is investigated for regulation of antioxidant-response and adaptive gene-expression programs.

Muscle & Metabolic Regulation

• Explored for direct interaction with casein kinase 2 (CK2) in skeletal muscle and effects on insulin signaling, GLUT4-related glucose handling, and mitochondrial bioenergetics.

Selected Research Highlights

• Metabolic Homeostasis: Landmark rodent studies reported prevention of diet-induced obesity and age-associated insulin resistance, with improved glucose handling in skeletal muscle models.

• AMPK Pathway Research: Extensively used to study AMPK-dependent metabolic switching, fatty-acid oxidation, and energy-sensor signaling.

• Exercise & Physical Performance Models: Investigated as an exercise-responsive peptide associated with improved running capacity and muscle metabolic function across age groups in mice.

• Mitochondrial Bioenergetics: Studied for effects on intrinsic mitochondrial efficiency, reduced ROS emission, and PGC-1α/AMPK-dependent muscle bioenergetic performance.

• Liver & NASH Models: Explored for interaction with Bcl-2 and improvements in mitochondrial metabolic pathways in experimental nonalcoholic steatohepatitis.

• Aging & Stress Adaptation: Circulating MOTS-c levels have been examined in relation to age and metabolic disease; nuclear translocation research focuses on adaptive stress-response gene programs.

Chemical & Handling Information

• Type: Synthetic 16-amino-acid mitochondrial-derived peptide

• Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)

• Molecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂

• Molecular Weight: ≈2174.6 g/mol

• Appearance: White to off-white lyophilized powder

Specifications

• Peptide: MOTS-c

• Amount: 20 mg per vial

• Form: Lyophilized powder

• Purity: ≥99% (HPLC) – Certificate of Analysis available per lot

• Packaging: Sealed vials suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place protected from light.

• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability according to laboratory SOPs.

• After reconstitution: Store at 2–8 °C for short-term use.

• Long-term storage: Aliquot and freeze at –20 °C or below. Avoid repeated freeze-thaw cycles.

Disclaimer

For Research Use Only. Not for human consumption, therapeutic, or diagnostic use. This product is intended solely for laboratory and scientific research purposes. Always follow your institution’s safety and handling guidelines. Certificate of Analysis (COA) available upon request.