KPV 10mg Research Peptide Vial

KPV 10 mg — Alpha-MSH Tripeptide Fragment for Anti-Inflammatory & Gut Barrier Research

Full Description

KPV (Lys-Pro-Val) is a synthetic tripeptide derived from the C-terminal sequence (amino acids 11–13) of alpha-melanocyte-stimulating hormone (α-MSH). It is extensively investigated in preclinical research for its potent anti-inflammatory properties, particularly in models of intestinal inflammation, while demonstrating minimal melanotropic activity compared to the parent hormone.

What It Is

• Class: Synthetic anti-inflammatory tripeptide (α-MSH fragment)

• Concept: Retains core immunomodulatory effects of α-MSH through receptor-independent and PepT1-mediated pathways, focusing on suppression of pro-inflammatory signaling without broad hormonal effects.

• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Anti-Inflammatory Signaling

• Inhibits NF-κB nuclear translocation and activation, reducing transcription of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8).

• Suppresses MAPK inflammatory pathways in epithelial and immune cells.

Cellular Uptake & Action

• Transported intracellularly via the PepT1 oligopeptide transporter in intestinal epithelial and immune cells.

• Accumulates in cells to directly modulate inflammatory cascades, independent of melanocortin receptors in many models.

Tissue Protection & Barrier Support

• Promotes mucosal healing and epithelial barrier integrity in inflamed tissues.

• Reduces oxidative stress and supports resolution of inflammation in gastrointestinal and dermal research models.

Selected Research Highlights

• Inflammatory Bowel Disease (IBD): Oral administration of KPV significantly reduced disease severity, histological damage, and pro-inflammatory cytokine expression in DSS- and TNBS-induced colitis models.

• Intestinal Barrier Function: Demonstrated PepT1-mediated uptake and attenuation of inflammation in human intestinal epithelial cell lines (Caco-2, HT-29) and immune cells.

• Cytokine Modulation: Nanomolar concentrations inhibit NF-κB and MAPK pathways, leading to reduced secretion of multiple inflammatory mediators.

• Dermatological & Wound Healing: Investigated for anti-inflammatory effects in skin models and potential support for barrier recovery.

• Neuroprotection & Systemic Inflammation: Explored in models of brain injury and systemic inflammation for reduced secondary damage and apoptosis.

Chemical & Handling Information

• Type: Synthetic tripeptide

• Sequence: Lys-Pro-Val (KPV)

• Molecular Formula: C₁₆H₃₀N₄O₄

• Molecular Weight: ≈342.44 g/mol

• Appearance: White to off-white lyophilized powder

Specifications

• Peptide: KPV

• Amount: 10 mg per vial

• Form: Lyophilized powder

• Purity: ≥99% (HPLC) – Certificate of Analysis available per lot

• Packaging: Sealed vials suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place protected from light.

• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability according to laboratory SOPs.

• After reconstitution: Store at 2–8 °C for short-term use.

• Long-term storage: Aliquot and freeze at –20 °C or below. Avoid repeated freeze-thaw cycles.