Epithalon 10mg Research Peptide Vial

Epithalon 10 mg — Synthetic Pineal Tetrapeptide for Telomerase & Longevity Research

Full Description

Epithalon (also known as Epitalon or AEDG) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the amino acid composition of epithalamin, a natural pineal gland extract. It is extensively investigated in preclinical research for its ability to activate telomerase, maintain telomere length, regulate pineal gland function, and exert geroprotective effects in models of aging and cellular senescence.

What It Is

• Class: Synthetic pineal tetrapeptide (bioregulator)

• Concept: Mimics select activities of pineal peptides to modulate telomerase activity, epigenetic regulation, and neuroendocrine signaling, supporting investigations into cellular longevity and age-related decline.

• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Telomerase Activation & Telomere Maintenance

• Upregulates telomerase reverse transcriptase (hTERT) expression and telomerase enzyme activity.

• Promotes telomere elongation in somatic cells, potentially counteracting replicative senescence in aging models.

Epigenetic & Gene Expression Modulation

• Interacts with histones (particularly H1 variants) to influence chromatin remodeling and gene transcription.

• Enhances expression of neurogenic differentiation markers and other longevity-related genes.

Antioxidant & Neuroendocrine Effects

• Exhibits antioxidant properties, supporting cellular protection against oxidative stress.

• Modulates pineal gland activity and melatonin synthesis in relevant research models.

Selected Research Highlights

• Telomere Biology: Demonstrated telomerase activation and telomere length extension in human cell lines and fibroblasts.

• Lifespan & Geroprotection: Investigated for lifespan extension and improved biomarkers of aging in rodent models.

• Neuroprotection & Neurogenesis: Studied for stimulation of neuronal differentiation markers (Nestin, GAP43, β-Tubulin III, Doublecortin) in stem cell models.

• Antioxidant Activity: Explored for enhancement of antioxidant enzyme systems and reduction of oxidative damage.

• Pineal & Melatonin Regulation: Shown to influence pineal gland function and melatonin production in preclinical settings.

• Retinal & Systemic Effects: Examined for potential benefits in models of retinal pigment epithelial cell stress and broader age-related decline.

Chemical & Handling Information

• Type: Synthetic tetrapeptide

• Sequence: Ala-Glu-Asp-Gly (AEDG)

• Molecular Formula: C₁₄H₂₂N₄O₉

• Molecular Weight: ≈390.35 g/mol

• Appearance: White to off-white lyophilized powder

Specifications

• Peptide: Epithalon (Epitalon)

• Amount: 10 mg per vial

• Form: Lyophilized powder

• Purity: ≥99% (HPLC) – Certificate of Analysis available per lot

• Packaging: Sealed vials suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place protected from light.

• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability according to laboratory SOPs.

• After reconstitution: Store at 2–8 °C for short-term use.

• Long-term storage: Aliquot and freeze at –20 °C or below. Avoid repeated freeze-thaw cycles.