Thymosin Alpha 1 Research Peptide Vial

Thymosin Alpha 1 5 mg (or 10 mg) — Immunomodulatory Peptide for Immune Function Research

(Adjust the mg amount to match your actual vial size.)

Full Description (Paste into the Description Box)

Thymosin Alpha 1 (Tα1) is a synthetic 28-amino acid peptide originally isolated from the thymus gland. It is extensively studied in preclinical and clinical research for its potent immunomodulatory properties, including enhancement of T-cell maturation and function, dendritic cell activity, and overall immune response regulation in models of infection, cancer, and immune deficiency.

What It Is

• Class: Immunomodulatory thymic peptide (Thymalfasin)

• Concept: Acts as a biological response modifier that restores and enhances immune function by promoting differentiation and activity of immune cells, particularly T-cells, while helping balance inflammatory responses.

• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Immune Cell Maturation & Activation

• Stimulates T-cell differentiation, maturation, and proliferation.

• Enhances dendritic cell antigen presentation and macrophage activity.

• Increases natural killer (NK) cell cytotoxicity.

Cytokine & Signaling Modulation

• Modulates production of cytokines and chemokines (e.g., increases IFN-γ, IL-2 while helping regulate excessive inflammation).

• Engages Toll-like receptors (TLR2, TLR9) to activate NF-κB and IRF3 pathways.

• Supports antibody responses and vaccine immunogenicity.

Additional Effects

• Demonstrates cytoprotective and anti-apoptotic effects in immune cells.

• Investigated for restoration of immune function in immunocompromised or stressed models.

Selected Research Highlights

• Infectious Disease: Studied for supporting immune responses against viral (Hepatitis B/C, influenza) and bacterial infections, and for reducing infection risk in sepsis or immunocompromised models.

• Cancer & Oncology: Explored as an adjuvant to enhance chemotherapy and immunotherapy efficacy while mitigating treatment-induced lymphopenia.

• Vaccine Enhancement: Shown to improve immune response to vaccines in elderly or immunocompromised research subjects.

• Autoimmune & Inflammatory Conditions: Investigated for balancing immune responses in models of chronic inflammation and autoimmune disease.

• Other Areas: Potential in mitigating cytokine storm, supporting immune recovery post-chemotherapy, and addressing immunosenescence.

Chemical & Handling Information

• Type: Synthetic 28-amino acid acetylated peptide

• Sequence: Ac-Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-OH

• Appearance: White to off-white lyophilized powder

Specifications

• Peptide: Thymosin Alpha 1 (Tα1)

• Amount:5 mg per vial

• Form: Lyophilized powder

• Purity: ≥99% (HPLC) – Certificate of Analysis available per lot

• Packaging: Sealed vials suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place protected from light.

• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability according to laboratory SOPs.

• Long-term storage: Aliquot and freeze at –20 °C or below. Avoid repeated freeze-thaw cycles.

• After reconstitution: Store at 2–8 °C for short-term use.